Mannose Binding Lectin Deficiency

Mannose-binding lectin deficiency: A rare but serious immune disorder

What is mannose-binding lectin deficiency?

Mannose-binding lectin (MBL) is a protein that plays an important role in the immune system. It helps the body to recognize and fight off infections caused by bacteria and viruses. MBL deficiency is a rare genetic disorder in which the body does not produce enough MBL. This can lead to an increased risk of infections, particularly in children.

Symptoms of MBL deficiency

The symptoms of MBL deficiency can vary depending on the severity of the disorder. Some people with MBL deficiency may have no symptoms at all, while others may experience frequent and severe infections. Common symptoms of MBL deficiency include:

• Recurrent respiratory infections, such as pneumonia, bronchitis, and sinusitis
• Ear infections
• Skin infections
• Urinary tract infections
• Sepsis

Diagnosis of MBL deficiency

MBL deficiency is diagnosed with a blood test. The test measures the level of MBL in the blood. A low level of MBL may indicate MBL deficiency.

Treatment of MBL deficiency

There is no cure for MBL deficiency. Treatment focuses on preventing and treating infections. Antibiotics are often used to treat infections in people with MBL deficiency. In some cases, immunoglobulin replacement therapy may be used to boost the immune system.

Prognosis of MBL deficiency

The prognosis for MBL deficiency varies depending on the severity of the disorder. Some people with MBL deficiency may live a normal life with few or no symptoms. Others may experience frequent and severe infections that can be life-threatening.

Research on MBL deficiency

There is ongoing research on MBL deficiency. Researchers are working to develop new treatments for the disorder. They are also studying the role of MBL in the immune system.